Medical Advances and Case Report

Combination, antiviral and cytotoxic exercises of some novel 2-Phenyl-3-Disubstituted Quinazolin-4(3H)- ones


Ogwang P. Engeu, Tumusiime Ralph and Agwaya Moses

The 2-phenyl-benzoxazin-4-ones were condensed with primary amine to form the 2, 3-disubstituted quinazolin-4(3H)-ones. Their chemical structure was elucidated by means of spectral (FT-IR, 1 H- NMR, MS) and elemental analysis. The antiviral activity and cytotoxicity of the compounds were tested in HeLa cells (vesicular stomatitis virus, Coxsackie virus B4 and respiratory syncytial virus), HEL cells [herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), vaccinia virus], Vero cells (parainfluenza-3, reovirus-1, Sindbis virus, Coxsackie virus B4 and Punta Toro virus). Among the new derivatives evaluated, specific antiviral activity was noted with compound QAA against vaccinia virus, parainfluenza-3 virus and Punta Toro virus, compound QOPD against HSV-1, HSV-2 and vaccinia virus, and compounds QONA and PDNFIN against Coxsackie virus B4.


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