Advances in Life Science and Biotechnology

Novel pyrazolyl pyridazine subordinates liable to have mitigating action


Florence Isabirye Muranga

Reaction of 4-acetyl-5,6-diphenylpyridazin-3(2H)-one (1) with diethyl oxalate in refluxing sodium ethoxide/ethanol mixture afforded ethyl 2,4-dioxo -4-(3-oxo- 5,6-diphenyl-2,3-dihydropyridazin4- yl)butanoate (2) which with hydrazine hydrate (1:1 mol) in refluxing ethanol afforded ethyl5- (3-oxo-5,6- diphenyl-2,3-dihydropyridazin 4- yl)-1H-pyrazole-3-carboxylate (3) while reaction of 2 with hydrazine hydrate (1:2 moles) in refluxing ethanol gave the corresponding acid hydrazide (4) . Reaction of acid chloride (6) with primary amines namely, aniline, p-toluidine and anisidine in the presence of DMF containing K2CO3 afforded the corresponding amide derivatives (7a – c). Hydrazones (9a – c) were prepared via the reaction of the acid hydrazide (4) with appropriate aldehydes namely, benzaldehyde, pchlorobenzaldehyde and p-nitrobenzaldehyde in refluxing ethanol/acetic acid mixture. Reaction of carboxylic acid hydrazide (4) with each of ethyl acetoacetate, acetylacetone and ethyl cyanoacetate gave the corresponding pyrazolone and pyrazole derivatives 11, 12 and 13 respectively.


Share this article

Get the App