Advance Journal of Virology, Epidemic and Pandemic Diseases

Plant-derived edible nanoparticles for cancer-drug delivery: Treating the natural way

Abstract


Ajay G. Namdeo, Ryan Varghese and Sahil Salvi

Background: The advent of nanomaterials has brought about a paradigm shift in the diagnosis, treatment, and prevention of various chronic diseases and cancer is no exception. While these nanoparticles are highly effective, they come with their own set of perils and caveats. These concerns form the basis for numerous scientific investigations for the development of nanomedicines. This article aims to review various Plant-derived edible Nanoparticles (PDNPs) for the management of symptoms associated with various tumors and cancers. Methods: To provide context and evidence, the relevant publications were identified on Google Scholar, PubMed, and Science-Direct using keywords such as plant-derived nanovesicles, plant-derived nanoparticles, cancer, tumors, and nanotechnology. Results: On several grounds, the Plant-derived edible Nanoparticles (PDNPs) have demonstrated great potential against various tumors and cancers, owing to their exceptional properties. These properties include their safety profile, high stability, low immunogenicity, easy and rapid internalization by mammalian cells, and massproduction capacity. These PDNPs were also studied to present potent antiinflammatory, anti-proliferative, regenerative, and immune modulatory properties, and are stable in the gastrointestinal tract upon oral administration. Conclusions: This article aims to critically review various PDNPs that have been studied over the years and to demonstrate their promising role in managing and alleviating the symptoms associated with cancers. However, more conclusive evidence is recommended from various preclinical and clinical studies to corroborate their safety, efficacy, and toxicity profiles in various patient cohorts, before establishing it as a novel drug delivery modality.

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