Journal of Science and Geosciences

Segregation, portrayal and antibacterial action screening of methoxyamine tetrahydroxyanthocyanidines from Detarium senegalense gmelin stem bark


Donatus Innocent, Lutho Zungu, Denise Hawkins and Evans Rosemary

Detarium senegalense F. Gmelin (Leguminasae) is well-known Nigerian food and medicinal plant,commonly used in phytomedicine to cure diseases and heal injuries. The ethanol stem barks extract of D. senegalense affords an anthocyanidin alkaloid (2-methoxyamine 3,4,5,7 – tetrahydroxyanthocynadines). The structure was elucidated using NMR spectroscopy in combination with IR and MS spectral data. Antibacterial studies showed that the isolated compound successfully inhibited Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis and Klebsiella pneumonia. This result authenticates the use of the plant in phytomedicine for the treatment ofinfections, disease prevention and as a preservative of local palm wine in South Eastern Nigeria.


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